Critical Care Science

Formerly Revista Brasileira de Terapia Intensiva

ISSN: 2965-2774

Free Online Access

Official Journal of the Associação de Medicina Intensiva Brasileira and the Sociedade Portuguesa de Cuidados Intensivos

Instructions for Authors

Critical Care Science (Crit Care Sci), ISSN 2965-2774 (formerly Revista Brasileira de Terapia Intensiva), is the scientific journal of the Brazilian Intensive Care Medicine Association (AMIB) and the Portuguese Society for Intensive Care (SPCI). It is a quarterly scientific publication aimed at disseminating relevant research related to critically ill patients, with discussion, distribution and promotion of evidence-based information for intensive care professionals.

General policies
Critical Care Science endorses the guidelines of the International Committee of Medical Journal Editors (ICMJE) Uniform Requirements for Manuscripts Submitted to Biomedical Journals, available at
All Critical Care Science content is licensed under a Creative Commons License (CCBY) International Attribution (
The authors of articles published in the journal are the copyright owners of the article and may grant any third party the right to use, reproduce or disclose their article under the terms of the CCBY adopted by the journal.
The journal Critical Care Science supports the clinical trial registration policies of the World Health Organization (WHO) and the ICMJE, recognizing the importance of these initiatives for the registration and dissemination of trial results to the international community through open access. According to this recommendation and the guidelines of the Latin American and Caribbean Center on Health Sciences Information (Pan American Health Organization (PAHO)/WHO for journals indexed in the Latin American and Caribbean Literature databases (Lilacs) and the Scientific Electronic Library Online (SciELO), Critical Care Science will only accept the publication of clinical trials that have been registered in clinical trials registries that meet the WHO and ICMJE requirements.
In addition, it is strongly recommended that authors observe the appropriate EQUATOR guidelines for each type of study in the Equator network (

Submission process
Manuscripts must be submitted in English or Portuguese. Critical Care Science is published in English and Portuguese. No fees are charged for the submission, evaluation or publication of manuscripts. Articles submitted in English will be translated by the journal into Portuguese, and articles submitted in Portuguese will be translated into English at no cost to the authors.
All articles must be submitted electronically to:

Authors must submit to the journal:

Cover letter - Must contain a statement attesting that the article is original and that it has not been and is not being submitted for publication in another journal. When applying, authors must declare that the study was approved by the Research Ethics Committee (REC). If necessary, during the peer review process, authors may be asked to send a copy of the CEP approval.
Declaration of conflict of interest - The conflicts of interest of all authors must be disclosed on the title page of the manuscript. Authors should download the appropriate form download it here) and, after signing, the authors should upload it during the submission process.
Funding - Information on possible sources of funding for the research will be required during the submission process, as well as on the title page of the manuscript.
Patient information - The written consent signed by the patient(s) or their guardians must be sent in the case of manuscripts that include clinical information or photographs, in which the patients may be individually identified.


Peer review process
All manuscripts submitted to Critical Care Science are subject to a rigorous review process. Initial submissions are reviewed by the editorial team to ensure adherence to Critical Care Science guidelines and policies, including ethical requirements for human and animal experimentation. Once the initial evaluation is complete, the article may be returned to the authors for adjustment.
Subsequently, the submitted manuscripts will be evaluated by the Editor-in-Chief. Manuscripts without merit, with significant methodological errors or that do not fit the editorial policy of the journal will be rejected, without the formal process of peer review. The average turnaround time for this immediate rejection is one week.
Manuscripts approved by the Editor-in-Chief (or a designated editor) will be sent to two or more reviewers. Reviewers will always be from institutions other than the origin of the manuscript, and anonymity will be maintained throughout the editorial process. Our average turnaround time for the first response to the authors is 30 days, although a longer period of time may be needed. After this evaluation, the editors will decide on acceptance, minor review, major review, rejection and resubmission or rejection.
After receiving the reviewers’ feedback, the authors must submit the revised version within 60 days, including the suggested changes and a point-by-point response to each reviewer suggestion. Authors may contact Critical Care Science ( if they need an extension. If it is not submitted within six months, the manuscript will be removed from the database, and any resubmission will follow the process of an initial submission. After resubmission, editors may choose to send the manuscript to external reviewers or make a decision based on their expertise.
The opinions expressed in the articles, including the reviewer requested changes, will be the only authors responsibility.

When reporting a study involving humans, their data or biological material, the authors must include a statement confirming that the study was approved (or that approval exemption was granted) by the institution’s Research Ethics Committee and/or the Ethics Committee for National Research, including the name of the committee, and certify that the study was conducted according to the ethical standards established in the Declaration of Helsinki of 1964 and its subsequent amendments or equivalent ethical standards. For studies conducted in Brazil, registration on the Plataforma Brasil and the Certificate of Presentation of Ethical Assessment (CAAE - Certificado de Apresentação de Apreciação Ética) is mandatory.
When reporting experiments on animals, the authors must indicate whether the institutional and national guidelines for the care and use of laboratory animals were followed and whether the experiments were approved by the competent Ethics Committee. In any clinical or experimental study, human or animal, this information should be included in the Methods section.
The ethics statements of Critical Care Science can be found on our website.

Anti-plagiarism policy
Any contributions submitted to Critical Care Science must be original, and the manuscript nor any part of it, must not be under consideration by any other journal. In addition, authors should not submit the same manuscript in different languages to different journals. Authors must declare any publications that may coincide at the time of submission for appreciation and evaluation by the editor. We submit the manuscripts to plagiarism detection tools to detect any duplication, redundant publication or misconduct. Whenever any of these situations are detected, the Editor-in-Chief will contact the authors and their institutions. If the editor identifies a situation of plagiarism, the authors will be subject to immediate rejection of the submitted manuscript. If the editor is unaware of the situation when accepting the manuscript, there will be a retraction in subsequent edition of the journal.

Information about article processing fees
The journal is completely free to access, and there are no fees for processing or publishing articles.

Authorship criteria
The journal assumes that all authors have agreed upon the content of the manuscript, given tacit consent to its submission and obtained the consent of the responsible authorities of the institute/organization where the study was conducted before submission.
Authors are advised to adhere to the authorship guidelines applicable to their specific field of research. In the absence of specific guidelines, it is recommended that authors whose names appear on the submission have:

  • - Contributed substantially to the conception or design of the work; the collection, analysis or interpretation of data; or the creation of new software used in the work.
  • - Written or revised the work critically regarding the relevant intellectual content.
  • - Approved the version to be published.
  • - Agreed to be responsible for all aspects of the publication to ensure that issues related to the accuracy or completeness of any part of the manuscript are properly investigated and resolved.


Open scientific practice
Although Critical Care Science supports open science communication practices, the journal will continue to use its current double-blind peer review model and will not require research data to be available in repositories. Authors may be asked to provide the raw data related to an article for editorial review, and they should be prepared to provide public access to such data (consistent with the ALPSP-STM Statement on Data and Databases) if practicable. It is desirable that data be kept for a reasonable period of time after publication.

General information

  • - The documents must not have been previously published.
  • - The corresponding author, who submits the article, is responsible for obtaining the agreement of the coauthors, if any.
  • - Failure to return corrections or other requests by the established deadline will result in rejection of the manuscript, regardless of the decision taken in its processing.
  • - Regarding the need to maintain the double-blind review policy, at this time, the journal will not publish articles that have already been deposited in preprint repositories. Articles will only be accepted for publication after the peer review process.
  • - Suggestions from three or more reviewers are accepted. Suggested reviewers should not be coauthors of other manuscripts in the past or have any conflicts of interest with the authors. This information will be requested during the submission process.


Types of manuscripts

Original article
It should fully describe, as concisely as possible, the results of the original research, containing all the relevant information for readers who wish to reproduce the research or evaluate the results and conclusions.
The text is limited to 3,500 words, excluding the title page, abstract, tables and references. Longer articles must be approved by the Editor-in-Chief. The original article must provide the Introduction, Methods, Results, Discussion and Conclusion sections.
The number of references is limited to 40. See the rules for references below.

Systematic or narrative review article
The review article is a comprehensive description of certain aspects of medical care important to the scope of the journal. It should not exceed 5,000 words (excluding the title page, abstract, tables and references) and six tables or figures. It must be written by authors with recognized experience. Reviews can be systematic or narrative. In systematic reviews, with or without meta-analysis, a Methods section is mandatory and should indicate the sources of evidence, the search strategies with the search terms and the article selection process, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) or other applicable guidelines. In narrative reviews, which seek to update knowledge on a specific topic from a theoretical or contextual point of view, it is not necessary to list the sources of information used, the methodology for searching the references, or the criteria used in the evaluation and selection of the studies. The narrative review article consists of the following sections: Introduction, Development (text divided into sections defined by the author, with titles and subtitles according to the approaches to the subject), Comments and References.

Brief communication
Original but shorter manuscripts addressing topics of interest in the field of intensive care, with preliminary results or results of immediate relevance. Manuscripts are limited to 1,500 words, 15 references and 2 tables or figures. The same sections for Original articles apply to Brief communications.

Special article
These are opinion articles written by experts to be read by the general medical community. Authors are usually invited by one of the editors, but unsolicited articles are also welcome and routinely evaluated for publication. These manuscripts should include evaluations of literature and data sources that critically review and evaluate existing knowledge on a particular subject. They are limited to 5,000 words and 6 tables or figures. In this category, the journal publishes guidelines and recommendations prepared by both AMIB and SPCI.

Letter to the Editor
The Letter to the Editor may contain original reports of unusual cases, comments on relevant scientific topics, criticisms of editorial policy or opinions about the content of the journal by up to four authors. Letters are limited to 500 words and 5 references.

Critical and in-depth comments, usually at the invitation of the Editors, but spontaneous editorials on topics relevant to Critical Care are welcome. They are limited to 1,000 words and 15 references.

Preparation of manuscripts
All articles must include the following:

Title page
The title page must contain the full title of the article, full names of all authors, institutional affiliation of all authors (only the main affiliation, i.e., the affiliation with the institution where the study was developed), author's full address for correspondence (including telephone, fax and e-mail), institution responsible for sending the article, source of funding for the projects and running title (alternative title of the article, up to 50 characters including spaces). The running title must appear on all pages in the header.

Abstracts must be presented in the same language as the manuscript, either in Portuguese or in English.
Abstracts of original articles are limited to 250 words. The use of abbreviations should be avoided as much as possible. The abstract must be structured (objective, methods, results and conclusion) and accurately reflect the main content of the text.
In the case of a brief communication, review article, special article, letter to the editor and editorial, a structured abstract is not required.

Six terms defining the subject of the work must be provided. Authors should base their approach on the Medical Subject Headings (MeSH) of the National Library of Medicines, available at, or in the Health Sciences Descriptors (DeCS) of the Virtual Health Library, available at

Body of text
The articles must be submitted in an MS Word® file, Times New Roman 12 font, double spaced, including tables, legends and references. In all categories of articles, citations must be numerical, superscripted and sequential.

Authors should use this section to recognize possible research funding and support from academic organizations, funding agencies, colleagues and other collaborators. It should be concise, not exceeding four lines.

Authors' contributions
The contribution of each author must be acknowledged in order to provide transparency regarding the contributions of each author in study conception, experimental design/programming, data collection, analysis of results, writing of the first draft, revision of the final version and approval.

References should be updated, preferably containing the most relevant articles published on the subject in the past 5 years. They must not contain articles that are not mentioned in the text, unpublished work or work deposited in preprint repositories. They must be numbered consecutively according to the citation sequence in the text and identified with Arabic numerals. The presentation must follow the Vancouver Style format, as in the following templates. The titles of journals should be abbreviated according to the National Library of Medicine, available in the List of Journal Indexed in Index Medicus, at
For all references, cite up to six authors. In the case of more than six authors, mention the first six followed by the expression “et al.”

Printed articles
Emanuel EJ, Persad G, Upshur R, Thome B, Parker M, Glickman A, et al. Fair allocation of scarce medical resources in the time of Covid-19. N Engl J Med. 2020;382(21):2049-55.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62.

Electronic articles
World Health Organization (WHO). Conceptual framework for the international classification for patient safety version 1.1: final technical report January 2009. Geneva: WHO; 2009 [cited 2022 Dec 12]. Available from:
São Paulo. Government of the State of São Paulo. Secretary of State for Health. Clinical Hospital, University of São Paulo School of Medicine. Activity report. Management Result Brightness in the Eyes. Years 2015 and 2016. [cited 2022 Jul 30]. Available in:

Chawla R, Dixit SB, Zirpe KG, Chaudhry D, Khilnani GC, Mehta Y, et al. ISCCM Guidelines for the Use of Non-invasive Ventilation in Acute Respiratory Failure in Adult ICUs. Indian J Crit Care Med. 2020;24(Suppl 1):S61-S81.

Hall JE. Guyton and Hall textbook of medical physiology. 13th ed. Philadelphia, PA: Elsevier; 2016.

Book chapters
Ricci Z, Romagnoli S. Technical complications of continuous renal replacement therapy. In: Bellomo R, Kellum JA, La Manna G, Ronco C, Editors. 40 years of continuous renal replacement therapy. Contributions to Nephrology. Basel: Karger; 2018. vol. 194, p. 99-108.

Tables and figures
All figures and tables must be numbered according to the order mentioned in the text. Tables and figures should be inserted after the references, only one on each page, and the figures should preferably be prepared in MS Excel®, or editable format, in 300 DPI files. They must also receive a title. Figures that require higher resolution should be sent in separate files. Figures with text must be provided in open files for translation. If this is not possible, the author must provide a translation.
Quantities, units and symbols used must comply with the rules in force in the country. Figures should have captions explaining the results, allowing for understanding without consulting the text. The legends of tables and figures should be concise, but self-explanatory, allowing comprehension without consulting the text. The units must be within the table and the statistical tests must be indicated in the legend.
Figures that have already been published must be accompanied by the authorization of the author/editor.
Reproduction of figures, graphs, diagrams or tables that do not originally belong to the article must refer to the source.

The use of acronyms should be avoided in the title of the article, abstract and titles of tables and figures. The use of acronyms should be minimized throughout the text. They must be preceded by the full name when mentioned for the first time in the text. Abbreviations, symbols and other meanings of signs must be provided in the footnotes of figures and tables.

Supplementary material
Supplementary material (text, tables, figures) must be presented as a single document in Word. Each element included in the supplementary material must be cited in the main text and numbered in order (for example, Complementary methods, Table 1S, Table 2S, Figure 1S, Figure 2S). Editors can decide whether the submitted material will be published.

Submission of the manuscript
Articles must be sent electronically to:

Indexed in

All journal content, except where noted, is licensed under a Creative Commons attribution-BY License . cc-by

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